B. Sepehri, K. Drew, J. A. Villegas*, Come for the atmosphere, stay for the interactions: Deciphering small molecule partitioning into biomolecular condensates. Cell Chemical Biology 30, P1337 (2023) *Corresponding Author
N. Daffern, K.Kelley, J.A. Villegas, I. Radhakrishnan, Prostaglandins as Candidate Ligands for a Per-ARNT-Sim (PAS) Domain of Steroid Receptor Coactivator 1 (SRC1). bioRxiv (2023)
T.M. Vaid, R. Demissie, Y.J. Kwon, T. Tran, H.G. Moon, J. A. Villegas, G.Y. Park, M.E. Johnson, H. Lee, Synergistic inhibition guided fragment-linking strategy and QSPR modeling to design inhalable therapeutics for asthma targeting CSF1R. ACS Omega 8, 20505 (2023)
J.A. Villegas*, T.M. Vaid, M.E. Johnson, T.W. Moore, Mapping the energy landscape of PROTAC-mediated protein-protein interactions. Comput. Struct. Biotechnol. J. 21, 1885 (2023) *Corresponding Author
E. Ticiani+, J. A. Villegas+, C. A. Murga-Zamalloa, A. Veiga-Lopez, Binding sites in the epidermal growth factor receptor are responsible for bisphenol S effects on trophoblast cell invasion. Chemosphere 318, 137960 (2023) +Equal Contribution
J. A. Villegas*, M. Heidenreich, E. D. Levy*, Molecular and environmental determinants of biomolecular condensate formation. Nat. Chem. Biol. 18, 1319 (2022) *Corresponding Author
X. Geng, C. Wang, X. Gao, P. Chowdhury, J. Weiss, J. A. Villegas, B. Saed, T. Perera, Y. S. Hu, J. C. Reneau, M. Sverdlov, A. Wolfe , N. A. Brown, P. W. Harms, N. G. Bailey, K. Inamdar , A. C. Hristov, T. Tejasvi, J. Montes, C. Barrionuevo, L. Taxa, D. S. Casavilca-Zambrano, L. A. D. Lage, H. F. Culler, J. Pereira, J. Runge, T. Qin, L. Tsoi, H. Hong, L. Zhang, C. A. Lyssiotis, R. Ohe, T. Toubai, A. Zevallos-Morales , C. Murga-Zamalloa, R. A. Wilcox, GATA-3 is a proto-oncogene in T-cell lymphoproliferative neoplasms. Blood Cancer Journal 12, 149 (2022)
S. D. Naidu, T. Suzuki, D. Dikovskaya, E. V. Knatko, M. Higgins, M. Sato, M. Novak, J. A. Villegas, T. W. Moore, M. Yamamoto, A. T. Dinkova-Kostova. The isoquinoline PRL-295 increases the thermostability of Keap1 and disrupts its interaction with Nrf2. iScience 25, 103703 (2022)
Prior to UIC:J. A. Villegas*, E. D. Levy*, A unified statistical potential reveals that amino acid stickiness governs nonspecific recruitment of client proteins into condensates. Protein Sci. 31, e4361 (2022) *Corresponding Author
J.A. Villegas+, N. J Sinha+, N. Teramoto, C. D. Von Bargen, D. J. Pochan, J. G. Saven, Computational design of single-peptide nanocages with nanoparticle templating. Molecules 27, 1237 (2022) +Equal Contribution
H. Garcia-Seisdedos+, J. A. Villegas+, E. D. Levy+, Infinite assembly of folded proteins in evolution, disease, and engineering. Angew. Chem. Int. Ed. 58, 2 (2019) +Equal Contribution
K. W. Pulsipher, J. Bulos, J. A. Villegas, J. G. Saven, I. J. Dmochowski, A protein–protein host–guest complex: Thermostable ferritin encapsulating positively supercharged green fluorescent protein. Protein Sci. 27, 1755 (2018)
K. W. Pulsipher, J. A. Villegas, B. W. Roose, T. L. Hicks, J. Yoon, J. G. Saven, I. J. Dmochowski, Thermophilic ferritin 24mer assembly and nanoparticle encapsulation modulated by interdimer electrostatic repulsion. Biochemistry 56, 3596 (2017).
J. Ping, K. W. Pulsipher, R. Vishnubhotla, J. A. Villegas, T. L. Hicks, S. Honig, J. G. Saven, I. J. Dmochowski, A. T. C. Johnson, Structural-functional analysis of engineered protein-nanoparticle assemblies using graphene microelectrodes. Chem. Sci. 8, 5329 (2017)
I. Sungwienwong, Z. M. Hostetler, R. J. Blizzard, J.J. Porter, C. M. Driggers, L. Z. Mbengi, J. A. Villegas, L. C. Speight, J. G. Saven, J. J. Perona, R. M. Kohli, R. A. Mehl, E. J. Petersson, Improving target amino acid selectivity in a permissive aminoacyl tRNA synthetase through counter-selection. Org. Biomol. Chem. 15, 3603 (2017).
H. V. Zhang, F. Polzer, M. J. Haider, Y. Tian, J. A. Villegas, K. L. Kiick, D. J. Pochan, J. G. Saven, Computationally designed peptides for self-assembly of nanostructured lattices. Sci. Adv. 2, e1600307 (2016